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The Future of Predictive Safety Evaluation Books

  • Autor: J. Marks
  • Editor: Springer
  • Relaese Date: 13 October 2011
  • ISBN: 9401083363
  • Format Book: PDF, Epub, DOCx, TXT
  • Number of page: 240 pages
  • File Size: 59MB
  • Rating:


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Description The Future of Predictive Safety Evaluation de J. Marks:

A. N. WORDEN, D. V. PARKE AND J. MARKS THE BACKGROUND There is nothing new about the fact that chemical substances derived either from natural products or by synthetic means .. can give rise to toxicity in animals and human beings, and that they must be subjected to controls. The earliest writings speak of such toxicity and, from the times of ancient Egypt and in the Old Tes- tament, controls have existed[l]. In the Middle Ages Paracelsus (1493-1541) noted that "All things are poisons, for there is nothing without poisonous qualities. It is only the dose which makes a thing a poison", and hence he stressed the importance of dose relative to toxic reactions [ 2] . Most of the early controls concentrated on substances that were to be deliberately administered to the human subject in the form of medicines. Legislation for many centuries was mainly con- cerned with regulating the activities of apothecaries and physicians. The Royal College of Physicians, for example, was originally established to control the activities of physicians within London. Among the controls which it exerted was that over the use of medicinal substances. Such controls were, however, poor, based as they were on hearsay evidence of toxicity. For many centuries no means existed for the accurate determination of toxicity. Info on the author is not uncovered and also may be taken away with the request from the publisher. Perhaps you could possibly be enthusiastic about some other books by the J. Marks. We were in a position to gather a lot of the most iformatsii to suit your needs. Intended for creators of these studies: our website would not extend to public accessibility the textbooks on our web sites solely starting details about the publication. If you feel web page is actually infringing, you need to write to people regarding it trouble with truly the publisher of the publications, we are going to punctually take out internet pages from internet site.

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